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Topically, nystatin has approval for treating mucocutaneous and cutaneous infections with Candida spp priligy dapoxetine amazon To better understand how pyruvate, either produced by the filarial host or introduced externally, regulates Wolbachia transcriptionally and thus metabolically, we measured the effects pyruvate had on the expression of two bacterial genes that encode enzymes known to use pyruvate as their substrate in a gluconeogenesis, where wBm0209 converts pyruvate to phosphoenolpyruvate P PEP the first step in gluconeogenesis; and b the TCA cycle, where wBm0207 performs the first reaction in converting pyruvate to Acetyl CoA, which then enters the TCA cycle to produce energy